Funded projects

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• The regulatory GENomE of SWine and CHicken: functional annotation during development

  EU Horizon Grant 817998 [€5,999,891] (2019-07-01~2023-06-30)

  Objectives: GENE-SWitCH aims to deliver new underpinning knowledge on the functional genomes of two main monogastric farm species (pig and chicken) and to enable immediate translation to the pig and poultry sectors. We will characterize the dynamics (“switches”) of the functional genome from embryo (chicken) and fetus (pig) to adult life by targeting a panel of tissues relevant to sustainable production. New expression QTL data in pigs and existing high-resolution QTL data in chicken will be used for developing innovative genomic predictive models that integrate functional annotations, and these models will be validated in commercial pig and poultry populations. In addition, nutritional epigenetic data will allow evaluation of the influence of maternal diet on the epigenome of the pig fetus and whether such effects persist until post-weaning. These open-shared datasets will conform fully with FAANG standards and add valuable knowledge on genetic and epigenetic variation of functional elements to FAANG.

  Project directors:

  • Elisabetta Giuffra (INRA, Division of Animal Genetics, France)
  • Hervé Acloque (INRA, Division of Animal Genetics, France)

  Additional Info: The consortium consists of 10 partners from nine European countries and represent both academia and industry.

  Contact: elisabetta.giuffra@inra.fr

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