Functional Annotation of ANimal Genomes (FAANG) Project
— A coordinated international action to accelerate Genome to Phenome
USDA NIFA Grant 2019-67015-29340 [$500,000] (2019-04-01~2021-03-31)
Objectives: 1) From a USDA NRSP8-supported biobank of material from two, well-phenotyped Thoroughbred stallions, collect whole-genome sequence and across-tissue gene expression to define the transcriptome and identify DNA variation. 2) Define regions of genome regulation, including four histone modification marks and a genomic insulator in eight tissues of high priority collected from these two Thoroughbred stallions; correlate with whole-transcriptome data and delineate sex differences by comparing these data to that in hand from two Thoroughbred mares. 3) Identify tissue-specificity and across-individual variation in the epigenetic determination of centromere position and its association with markers of genome regulation while concurrently determining the role of non-centromeric CENP-A binding sites in genome function.
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